Yes, it is possible for Housing Hand to accept applicants who are on housing benefit. When making the application, you will need to select 'working professional'.
The criteria for a working professional application is that you will need to provide proof of a monthly income that equals or is larger than their 1.5x the monthly rent. (For example, if the monthly rent was £500, you will need to provide proof of an income of £750 a month).
Housing Hand can accept applicants who are on housing benefits if they are able to provide proof of earning 1.5x the monthly rent excluding the housing benefits contribution.